IMMUNE CHECKPOINT INHIBITORS PLUS DEBULKING SURGERY FOR PATIENTS WITH METASTATIC RENAL CELL CARCINOMA: CLINICAL OUTCOMES AND IMMUNOLOGICAL CORRELATES OF A PROSPECTIVE PILOT TRIAL

Abstract Surgical removal of primary tumors reverses tumor-mediated immune suppression in pre-clinical models with metastatic disease.However, how cytoreductive surgery in the metastatic setting modulates the immune responses in patients, especially in the context of immune checkpoint therapy (ICT), is not understood.We report the first prospective

Consumption is one of the main economic characters of any society, in a way that the proper ratio between production and consumption in the economy is necessary.One of the principles of economics, the apparent difference in economic systems based on human thought and the Islamic economic system, is the parsimony contradiction principle or the sting

Abstract Hollow fiber membranes are used in industrial Salves processes widely.Porosity is one of the important parameters affecting the humidification performance of hollow fiber membrane components.The aim of this study was to analyze the effect of porosity of hollow fiber membrane on humidification performance.In order to perform this analysis,

Background and Objective: Total hip arthroplasty [THA] is frequently performed in Egypt for patients with degenerative joint disease.This procedure is performed under general anaesthesia and is associated with severe postoperative pain.Pregabalin has been described as an effective adjuvant for spinal anaesthesia.However, its optimum dose has not be

Electrorefining is a key step in pyroprocessing.The solid cathode processing is necessary to separate the salt from the cathode of the electrorefiner since the uranium deposit in a solid cathode contains electrolyte salt.Moreover, it is very important to increase the throughput of the salt separation system due to the high uranium content of the sp